Mutation-derived Neoantigen-specific T-cell Responses in Multiple Myeloma
نویسندگان
چکیده
منابع مشابه
Antigen-specific T-cell Responses with Antigen-expression and Immunoparalysis in Multiple Myeloma
Running title: Antigen-expression and specific T-cell responses in Myeloma th framework program OVER-MyR. Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Despite a variety of therapeutical approaches including high dose chemotherapy with subsequent autologous stem cell transplantation, Multiple Myeloma remains an almost incurable disease. Ne...
متن کاملAssociation of antigen-specific T-cell responses with antigen expression and immunoparalysis in multiple myeloma.
PURPOSE Cancer testis antigens (CTA) are immunotherapeutical targets aberrantly expressed on multiple myeloma cells, especially at later stages, when a concomitant immunoparesis hampers vaccination approaches. EXPERIMENTAL DESIGN We assessed the expression of the multiple myeloma antigen HM1.24 (reported present in all malignant plasma cells) and the CTAs MAGE-A2/A3 and NY-ESO-1 (aberrantly e...
متن کاملHigh somatic mutation and neoantigen burden are correlated with decreased progression-free survival in multiple myeloma
Tumor-specific mutations can result in immunogenic neoantigens, both of which have been correlated with responsiveness to immune checkpoint inhibitors in highly mutagenic cancers. However, early results of single-agent checkpoint inhibitors in multiple myeloma (MM) have been underwhelming. Therefore, we sought to understand the relationship between mutation and neoantigen landscape of MM patien...
متن کاملNovel and shared neoantigen for glioma T cell therapy derived from histone 3 variant H3.3 K27M mutation
Background and purpose Malignant gliomas, such as glioblastoma (GBM) and diffuse intrinsic pontine gliomas (DIPG), are lethal brain tumors in both adults and children. Indeed, brain tumors are the leading cause of cancer-related mortality and morbidity in children. Children with DIPG have one-year progression-free survival rates below 25%, and median overall survival of 9 to 10 months with curr...
متن کاملBiology of Human Tumors Association of Antigen-Specific T-cell Responses with Antigen Expression and Immunoparalysis in Multiple Myeloma
Purpose: Cancer testis antigens (CTA) are immunotherapeutical targets aberrantly expressed on multiple myeloma cells, especially at later stages, when a concomitant immunoparesis hampers vaccination approaches. Experimental Design: We assessed the expression of the multiple myeloma antigen HM1.24 (reported present in all malignant plasma cells) and the CTAs MAGE-A2/A3 and NYESO-1 (aberrantly ex...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2019
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-19-2309